{"product_id":"osteo-k-minis","title":"Osteo-K Minis","description":"\u003cul\u003e\n\u003cli\u003eMaintains strong bones\u003c\/li\u003e\n\u003cli\u003eSupports healthy bone density and bone matrix\u003c\/li\u003e\n\u003cli\u003ePromotes healthy bone marrow\u003c\/li\u003e\n\u003cli\u003eSupports healthy immunity and healthy inflammation balance\u003c\/li\u003e\n\u003cli\u003eActivates genes that produce healthy bone collagen\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAdequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis. Osteo-K\u003cspan\u003e®\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eprovides additional nutritional support by combining calcium and vitamin D3 with MK4\u003cspan\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTo meet the people's unique nutritional needs, NBI created three versions of Osteo-K: original Osteo-K\u003c\/span\u003e\u003cspan\u003e for those who need more calcium, Osteo-K Minis with less calcium, and calcium-free Osteo-MK4\u003csup\u003e®\u003c\/sup\u003e. If you're unsure which product is right for you, click \u003c\/span\u003e\u003ca href=\"https:\/\/nbihealth.com\/bone-support\/\"\u003e\u003cspan\u003ehere\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIn addition to providing 400 mg\/day of calcium (as calcium citrate) and 2000 IU daily of vitamin D3, Osteo-K Minis also delivers 45 mg of MK4 daily.\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eClinical Trials:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003eMore than 25 clinical trials involving over 7000 people show that MK4 (45 mg\/day in divided doses) maintains strong bones. One meta-analysis of clinical trials concluded that MK4 (45 mg daily) maintains strong bones, as indicated by 70% fewer fractures in clinical trial volunteers (Cockayne S et al. 2006;166(12):1256-1261).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAnother review of the data that evaluated 19 randomized, controlled clinical trials involving 6,759 volunteers reached the same conclusion--MK4 (45 mg\/day in divided doses) maintains strong bones as indicated by reducing fractures in clinical trials (Huang ZB et al. 2015;26(3):1175-1186).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eA more recent systematic review and meta-analysis published in 2022 confirmed the earlier research. This study pooled data from 10 randomized, controlled clinical trials with 5,413 women ages 45-81. The data showed that MK4 promotes maintaining strong bones, as indicated by 62% fewer fractures in volunteers (Ma ML et al. 2022;10:979649).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eStudies show that combining MK4 with vitamin D3 provides greater benefits than taking MK4 alone. A two-year clinical trial with 172 women (average age 53 years old) divided the volunteers into four groups. They took MK4 (45 mg\/day) alone, vitamin D3 alone, or a combination of MK4 plus vitamin D3. The fourth group acted as a control and only received some dietary counseling. All women had low bone mineral density at the beginning of the study. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNot only did bone mineral density significantly increase more in the MK4+D3 group compared to the other groups, but this improvement was already evident after just six months of taking the nutrients. After two years, 67.8% of the volunteers taking MK4+D3 had their bone density increase by 2% or more, while 45.2% had a 5% or greater increase in bone density (Ushiroyama T, et al. 2002;41(3):211-221.)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAnother two-year randomized clinical trial divided 92 women (mean age about 64) into four groups. The women took MK4 (45 mg\/day) alone, vitamin D3 alone, the combination of MK4 (45 mg\/day) plus vitamin D3, or only calcium (as calcium lactate, 2 grams\/day). The best results were noted in the volunteers who took MK4 plus D3. In this group, bone density increased 1.49% during the first year and 1.35% after two years.\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e(Iwamoto J, et al. 2000;5(6):546-51.)\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eA third clinical trial showed MK4 was the key additional nutrient. The study lasted six months and gave 78 women ages 61 to 74 either MK4 (45 mg\/day), vitamin D3 and calcium, or only vitamin D3 and calcium. Bone density only increased in those taking the MK4. (Je SH, et al. 2011;26(8):1093-8.)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003cstrong\u003eSafety:\u003c\/strong\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nbihealth.com\/wp-content\/uploads\/2023\/05\/NBI-MK4-Osteo-Research-Updated-2023.pdf\"\u003e\u003cspan\u003eClinical trials\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e published in medical journals document over 7,000 people taking 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eCAUTION: People taking the anticoagulant medication warfarin (Coumadin) should not take this product since vitamin K interferes with this medication.\u003c\/p\u003e\n\u003cp\u003eDirections: Take two capsules twice daily with meals.\u003c\/p\u003e\n\u003cp\u003e120 capsules per bottle, a 30-day supply\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMore than 100\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/nbihealth.com\/bone-support\/#OsteoK-citations\" target=\"_blank\"\u003e\u003cspan\u003ecitations\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e support the ingredients in Osteo-K, Osteo-K Minis, and Osteo-MK4's ingredients for bone health, cardiovascular health, and immune support.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFor full information, download the product leaflet:\u003cbr\u003e\u003cstrong\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0683\/6745\/0200\/files\/Osteo-K_Minis_Lot_2503177_COA.pdf?v=1773895888\" target=\"_blank\" rel=\"noopener\"\u003eOsteo-K Minis Certificate of Analysis\u003c\/a\u003e\u003c\/strong\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0683\/6745\/0200\/files\/FDA_registration_valid_till_12-31-2026.pdf?v=1773895889\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eOsteo-K Minis FDA Registration\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"AG Biomed","offers":[{"title":"Default Title","offer_id":43520788856920,"sku":null,"price":0.0,"currency_code":"THB","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0683\/6745\/0200\/files\/AGB_Osteo-KMinis_size300x300px-01.jpg?v=1766057923","url":"https:\/\/agbiomed.com\/products\/osteo-k-minis","provider":"AG Biomed","version":"1.0","type":"link"}